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MK-4827 hydrochloride
CAS No. 1038915-64-8
MK-4827 hydrochloride( Niraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride )
Catalog No. M10195 CAS No. 1038915-64-8
A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
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| 5MG | 50 | In Stock |
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| 10MG | 72 | In Stock |
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| 25MG | 107 | In Stock |
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| 50MG | 132 | In Stock |
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| 100MG | 205 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK-4827 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
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DescriptionA highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2; inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10?100 nM range; well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.Ovarian Cancer Approved.
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In Vitro——
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In Vivo——
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SynonymsNiraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP
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Research AreaCancer
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IndicationOvarian Cancer
Chemical Information
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CAS Number1038915-64-8
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Formula Weight356.8492
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Molecular FormulaC19H21ClN4O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N.Cl
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Chemical Name2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jones P, et al. J Med Chem. 2009 Nov 26;52(22):7170-85.
2. Bridges KA, et al. Oncotarget. 2014 Jul 15;5(13):5076-86.
3. Mirza MR, et al. N Engl J Med. 2016 Dec 1;375(22):2154-2164.
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