MK-4827 hydrochloride

CAS No. 1038915-64-8

MK-4827 hydrochloride( Niraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride )

Catalog No. M10195 CAS No. 1038915-64-8

A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 31 In Stock
5MG 50 In Stock
10MG 72 In Stock
25MG 107 In Stock
50MG 132 In Stock
100MG 205 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    MK-4827 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
  • Description
    A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2; inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10?100 nM range; well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.Ovarian Cancer Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Niraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    Cancer
  • Indication
    Ovarian Cancer

Chemical Information

  • CAS Number
    1038915-64-8
  • Formula Weight
    356.8492
  • Molecular Formula
    C19H21ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N.Cl
  • Chemical Name
    2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jones P, et al. J Med Chem. 2009 Nov 26;52(22):7170-85. 2. Bridges KA, et al. Oncotarget. 2014 Jul 15;5(13):5076-86. 3. Mirza MR, et al. N Engl J Med. 2016 Dec 1;375(22):2154-2164.
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